Fig. 3: Tripartite model of primate STN presented next to a recent model of molecular organization within mouse STN.
a Tripartite model of primate STN; motor, associative and limbic territories based on multiple anatomical-functional studies (references in main text). Drawing based on original illustration in Benarrouch, 2008; here updated with information of afferent and efferent projections as outlined by Baunez et al., 2016. Abbreviations: GPe, globus pallidus externa; GPi, globus pallidus interna; SNr, substantia nigra pars reticulata; SNc, substantia nigra pars compacta; PPN, pedunculopontine nucleus; VTA, ventral tegmental area. b Gene expression patterns spatially mapped in brain sections using fluorescent in situ hybridization (FISH) (original data reprinted in Fig. 2) allowed the outlining of molecularly profiled domains within mouse STN: STNa (ventromedial STN), STNb (central STN), STNc (dorsal STN), STNds (dorsal strip of STN showing GABA-positive, rather than glutamatergic, mRNA profile). Gene expression (mRNAs) present throughout the STN structure listed in the text box; unique gene expression patterns distinct for each domain listed under the domain name. c Selected mRNAs, their distribution and extent of co-localization with STN marker Pitx2, as described in the mouse STN. b, c: For mRNA full name, see main text. Illustrations based on original publication (Wallén-Mackenzie et al. 67; published under Open access).
