Fig. 1: Bi-direction Miami plot showing associations between DNA methylation and birth order. | Communications Biology

Fig. 1: Bi-direction Miami plot showing associations between DNA methylation and birth order.

From: A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation

Fig. 1: Bi-direction Miami plot showing associations between DNA methylation and birth order.

Bi-directional Miami plot showing the results of meta-analysis of the association between DNA methylation and birth order, adjusting for sex, maternal age, gestational age, birthweight, maternal smoking, batch effects, selection factor, and cell proportions. Directions of the associations were shown on the Y-axis, with positive associations above Y = 0 and negative associations below. Threshold of significance after false-discovery rate (FDR) correction is shown in a dashed horizon line. A total of 341 CpGs were significant after FDR multiple correction, the threshold of which was shown with a dashed line.

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