Table 2 Top 25 significant CpGs associated with ascending birth order from meta-analysis.

From: A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation

cpg

Effect

Raw P value

FDR adjusted P value

Coefficient direction

P heta

Relation to Island

UCSC RefGene Name

UCSC RefGene Group

cg09249800

−0.0023

9.60E−12

7.24E−06

+-?-?----?+-?--?---+??b

0.002

Island

ACOT7

Body

cg26262573

0.0078

8.31E−10

3.00E−04

++++++++++-++++-++-+++

0.005

S_Shore

LOC650226

TSS200

cg26776957

−0.0028

1.27E−09

3.00E−04

------------------+-+-

0.841

OpenSea

PLEKHB1;PLEKHB1

TSS200;TSS1500

cg26865747

−0.0105

1.62E−09

3.00E−04

+-?-----------+--?---+

0.003

N_Shore

  

cg11699125

−0.0023

1.99E−09

3.00E−04

+---?-----+----+--+---

0.000

Island

ACOT7

Body

cg03779117

0.0034

2.86E−09

3.59E−04

+++++++++++--++++++--+

0.926

Island

  

cg09377704

0.0025

5.11E−09

4.40E−04

++++++++++++----++++--

0.579

N_Shore

  

cg04654716

−0.0023

5.12E−09

4.40E−04

----+----+-+---+-+--+-

0.113

S_Shore

FAM169A

TSS1500

cg19539004

0.0017

5.25E−09

4.40E−04

-+++++++++++-+++++++++

0.589

S_Shore

LIF

TSS1500

cg12763978

−0.0064

7.13E−09

4.82E−04

+-?-+------+--+--++---

0.018

N_Shore

  

cg05335315

0.0011

7.43E−09

4.82E−04

+++++++++-++-+++++-+++

0.647

OpenSea

JAG2

TSS1500

cg17328716

0.0056

7.67E−09

4.82E−04

++++++++++-+++++++-+++

0.062

S_Shore

LOC650226

TSS200

cg20534570

0.0023

1.49E−08

8.57E−04

-+++++-++-+---+++-++-+

0.048

OpenSea

TEF

TSS1500

cg25738326

0.0015

1.70E−08

8.57E−04

-+++++-+++++-++++-++++

0.035

OpenSea

  

cg22608655

0.0021

1.70E−08

8.57E−04

-+++++++++++-+++++++++

0.180

N_Shore

PYGO2

Body

cg15730180

0.004

2.03E−08

9.58E−04

++++-++++++-++-++++-++

0.552

N_Shore

  

cg20014974

0.0026

2.26E−08

1.00E−03

++++-+++++++++-+-+++-+

0.761

N_Shore

  

cg26443093

−0.0012

2.40E−08

1.00E−03

+---+-------++-++--+--

0.662

N_Shore

ZFPM1

Body

cg01649647

−0.0013

3.28E−08

1.30E−03

+---?--------++-++----

0.185

OpenSea

MYL9

Body

cg00741634

0.0021

3.50E−08

1.32E−03

-+++++++++++-+-++-+--+

0.599

S_Shore

KIAA0892;SF4

Body; TSS1500

cg17675882

8.00E−04

4.29E−08

1.46E−03

+++++++-+---+++++-++++

0.041

N_Shore

NDRG3

5’UTR

cg03122674

0.0068

4.42E−08

1.46E−03

++++-+++++-++++-++-+++

0.011

Island

LOC650226

Body

cg15134787

0.0062

4.45E−08

1.46E−03

++++-++++++++++-++++++

0.084

N_Shore

  

cg02119982

−3.00E−04

6.41E−08

1.88E−03

-++-------+---+-+?---+

0.417

OpenSea

NOD2

Body

cg22019158

0.0015

6.70E−08

1.88E−03

+++++++++++-++++--++++

0.185

N_Shelf

AHDC1

5’UTR

  1. aP het: Heterogeneity P values output by METAL
  2. bThe direction of association between later birth order and DNA methylation is positive (+) or negative (−) in each cohort. Cohorts are ordered from the largest to the smallest. If the CpG was not assessed in a cohort (due to its being missed on the array) a “?” will be displayed.
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