Fig. 3: Functional alteration in gut microbiome of excess body weight and lean CRC patients.

a Volcano plots of differential KO genes in excess body weight (EBW) and lean CRC patients compared to CTR. b Venn diagram of the differential KO genes in the EBW and the lean groups. c Bubble chart shows the important part of significantly differential functional pathways in the EBW and the lean groups, with red dot indicating increased abundance, and blue dot decreased abundance. The size of dots indicates the degree of the alteration.