Fig. 10: Regulation of σE and a model of regulation by σE.
From: σE of Streptomyces coelicolor can function both as a direct activator or repressor of transcription
σE binds to RNAP to form holoenzyme and binds to promoters where three possible scenarios can occur (i) σE is the only regulator of the gene; (ii) σE is one of two or more regulators; (iii) σE is bound to the promoter, either occluding and overlapping another promoter or forming a barrier against RNAP that has initiated transcription from upstream promoters. σE-dependent transcription can possibly be also modulated by additional binding partners such as ApgA, CarD, BldC, and DNA binding proteins NdgR, Lsr2.
