Fig. 4: Molecular basis for the species-specific flavivirus NS5–hSTAT2 binding.
From: A conformational selection mechanism of flavivirus NS5 for species-specific STAT2 inhibition
a Structural superposition between hSTAT2-bound DENV2 NS5 and ZIKV NS5 (PDB 6WCZ), with two structurally divergent regions shown in expanded views. b Surface mapping of the hSTAT2-interaction sites (magenta) in DENV2 NS5. The hSTAT2 ND- and CCD-binding sites are circled in dotted lines. c Surface view of the hSTAT2-interaction sites (magenta) in ZIKV NS5 (PDB 6WCZ). d Surface view of the potential hSTAT2-interaction sites (magenta) of YFV NS5 (PDB 6QSN), identified by sequence and structural comparison with DENV2 NS5. e Structural model of full-length WNV NS5, with residues bearing sequence and structural similarity to the hSTAT2-binding sites in DENV2 NS5 colored in magenta.
