Fig. 3: Ketogenic diet activates CREB and ERK but not CaMKII in the hippocampus of APP/PS1 mice. | Communications Biology

Fig. 3: Ketogenic diet activates CREB and ERK but not CaMKII in the hippocampus of APP/PS1 mice.

From: Ketogenic diet and BHB rescue the fall of long-term potentiation in an Alzheimer’s mouse model and stimulates synaptic plasticity pathway enzymes

Fig. 3

a–d Relative protein level of phospho-CREB, phospho-ERK, phospho-CaMKII, and PSD95. Six-month treatment with a ketogenic diet increases the activation of CREB and ERK in APP/PS1 mice but does not affect CaMKII or PSD95 (n = 6). e Representative immunoblot of phosphorylated and total proteins. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01. Two-way ANOVA tests show significant differences between diet treatments in phospho-ERK: F(1,20) = 19.97, p < 0.001; phospho-CREB: F(1,20) = 10.84, p = 0.004; phospho-CamKII: F(1,19) = 5.344, p = 0.032.

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