Fig. 5: Ketogenic diet increases BDNF level in the hippocampus of female APP/PS1. | Communications Biology

Fig. 5: Ketogenic diet increases BDNF level in the hippocampus of female APP/PS1.

From: Ketogenic diet and BHB rescue the fall of long-term potentiation in an Alzheimer’s mouse model and stimulates synaptic plasticity pathway enzymes

Fig. 5

a Representative immunoblot and quantitative analysis (b, c) of BDNF dimer and monomer in the hippocampus of APP/PS1 mice. KD-fed female mice show increased BDNF dimer. n = 6. d Hippocampal BDNF level in APP/PS1 mice detected by ELISA. KD-fed female mice show increased levels of brain-derived neurotrophic factor compared to CD-fed littermates. n = 5. Data are presented as mean ± SEM. *p < 0.05. Two-way ANOVA tests show significant differences between diet treatments (F(1,20) = 9.156, p = 0.007) and gender differences (F(1,20) = 4.914, p = 0.038) in BDNF dimer. The analysis also shows significant gender differences in total BDNF (F(1,16) = 4.540, p = 0.049).

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