Fig. 6: A biochemical model of pathways supporting Synaptic Plasticity. | Communications Biology

Fig. 6: A biochemical model of pathways supporting Synaptic Plasticity.

From: Ketogenic diet and BHB rescue the fall of long-term potentiation in an Alzheimer’s mouse model and stimulates synaptic plasticity pathway enzymes

Fig. 6

Glutamatergic receptors (AMPA and NMDA), intracellular Ca2+, and TrkB activity stimulate the phosphorylation of ERK and CaMKII, which subsequently enhance the phosphorylation of CREB. Activation of CREB regulates gene expression necessary for the formation of long-term memory, including BDNF. A ketogenic diet increases the phosphorylation of the ERK/CREB pathway, increasing BDNF production and synaptic plasticity.

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