Fig. 3: Lack of the PCT/CT transcript exacerbates loss of subchondral trabecular bone. | Communications Biology

Fig. 3: Lack of the PCT/CT transcript exacerbates loss of subchondral trabecular bone.

From: Transcript-dependent effects of the CALCA gene on the progression of post-traumatic osteoarthritis in mice

Fig. 3

a Micro-CT-based, quantitative analysis of tibial subchondral trabecular bone of the bone volume fraction (BV/TV), trabecular numbers (Tb.N), trabecular thickness (Tb.Th), and trabecular separation (Tb.Sp) at the indicated time points in WT mice after sham or ACLT surgery. b Representative micro-CT coronal views of tibial subchondral trabecular bone of diseased (OA) and contralateral control (Ctrl) knees from the indicated groups 4 and 8 weeks after ACLT (scale bar = 500 μm). c Relative alterations at the indicated time points (ACLT vs. contralateral healthy controls) in BV/TV, Tb.N, Tb.Th and Tb.Sp, expressed as fold differences. n = 7,8 biologically independent animals as indicated per group and time point. For a unpaired two-tailed students t-test and for c ordinary one-way ANOVA was used and to calculate differences. Box plots represent median with minimum and maximum whiskers. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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