Fig. 4: Mice lacking the PCT/CT transcript display indices of increased bone resorption in subchondral bone after ACLT. | Communications Biology

Fig. 4: Mice lacking the PCT/CT transcript display indices of increased bone resorption in subchondral bone after ACLT.

From: Transcript-dependent effects of the CALCA gene on the progression of post-traumatic osteoarthritis in mice

Fig. 4

a Histomorphometric analysis of osteoclast surface per bone surface (Oc.S/BS) and numbers of osteoclasts per bone perimeter (Oc.N/B.Pm) at the indicated time points in TRAP-stained ptOA sections. b Representative TRAP-stained images of tibial subchondral bone of ptOA knees 4 weeks after ACLT (scale bar = 50 μm). c Quantification of Oc.S/BS and Oc.N/B.Pm in mutant and WT mice at the indicated timepoints. n = 7,8 biologically independent animals as indicated per group and time point. For a unpaired two-tailed students t-test and for c ordinary one-way ANOVA was used to determine differences. Box plots represent median with minimum and maximum whiskers. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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