Fig. 5: Inactivation of the αCGRP transcript results in reduced osteophyte formation. | Communications Biology

Fig. 5: Inactivation of the αCGRP transcript results in reduced osteophyte formation.

From: Transcript-dependent effects of the CALCA gene on the progression of post-traumatic osteoarthritis in mice

Fig. 5

a Representative 3-dimensional micro-CT reconstruction of the osteophytes (red) in ptOA knees from the indicated groups 4 and 8 weeks after surgery (scale bar = 1 mm). b Quantitative evaluation of osteophyte volume in the total joint as well as femoral and tibial compartments at the indicated time points. c Representative histological images of femoral osteophytes from indicated groups stained with BIC at indicated time points (scale bar = 200 μm). d Semi-quantitative grading of the maturity and size of osteophytes in the total joint, femoral and tibial compartments at the indicated time points. n = 7,8 biologically independent animals as indicated per group and time point. Ordinary one-way ANOVA was used to determine statistical differences. Box plots represent median with minimum and maximum whiskers. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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