Fig. 6: Pathway crosstalk for critical Covid-19.
From: Priority index for critical Covid-19 identifies clinically actionable targets and drugs
It was identified from pathway-derived gene interactions but constrained by target gene prioritisation information (i.e., target index). a Gene-centric representation of the crosstalk, with nodes labelled by ‘gene symbol @ priority rank’ and color-coded by priority rating (target index). The crosstalk involves highly prioritised and interconnected genes. Genes targeted by drugs in phase-III clinical trials for Covid-19 are highlighted in bold. b Venn diagram illustrating the overlap between crosstalk genes and Covid-19 phase-III drug targets. The statistical significance (P-value), odds ratio, and its 95% CI were calculated using one-sided Fisher’s exact test. c Tabular display of crosstalk genes also being Covid-19 phase-III drug targets, along with information on drug candidates and mechanisms of action. d Kite-like plot for KEGG pathways enriched in crosstalk genes. Enrichment significance (FDR) was calculated using one-sided Fisher’s exact test. Each kite is sized by the number of member genes (indicated by blue dots beneath). Abbreviations include CCR (cytokine-cytokine receptor) and TNF (tumor necrosis factor). e Pathway-centric representation of the crosstalk, with node size indicating the number of pathway member genes, and edge thickness proportional to the number of shared genes between two-endpoint pathways.
