Fig. 8: Inflammation and STAT3 signaling pathway changes in skin wounds of Mir221 knockout mice. | Communications Biology

Fig. 8: Inflammation and STAT3 signaling pathway changes in skin wounds of Mir221 knockout mice.

From: MicroRNA-221-3p inhibits the inflammatory response of keratinocytes by regulating the DYRK1A/STAT3 signaling pathway to promote wound healing in diabetes

Fig. 8: Inflammation and STAT3 signaling pathway changes in skin wounds of Mir221 knockout mice.The alternative text for this image may have been generated using AI.

Representative immunohistochemistry images and summary data showing myeloperoxidase (MPO) (a), CD68 (b) and DYRK1A (c) expression levels in skin wound tissues of wild type (WT) and Mir221 knockout (KO) mice. Data are presented as mean ± SEM (n = 5–8). Scale bars, 50 μm in (a, b), 5 μm in (c). d Representative images and summary data showing expression levels of phosphorylated (p)-STAT3 (Tyr705), p-STAT3 (Ser727), total STAT3, and DYRK1A in skin wound tissues of WT and Mir221 KO mice. Vertically stacked strips of bands in a figure are not derived from the same membrane in any case. Data are presented as mean ± SEM (n = 5), *P < 0.05.

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