Fig. 2: Trazodone attenuates sensory stimulation-induced functional hyperemia and astrocyte Ca²⁺ responses.

a Schematic of the experimental design. b Summary data showing basal penetrating arteriole cross-sectional area and endfoot Ca²⁺ in control and trazodone-treated mice. c Time course of arteriolar cross-sectional area (top) and endfoot Ca²⁺ transients (bottom) in control (left) and trazodone-treated (right) mice. Gray traces show responses to individual trials. d Summary data showing peak percent change in penetrating arteriole dilation and astrocyte Ca²⁺ responses (%) at the endfoot, soma, and arbor in response to 5-s whisker stimulation in the presence or absence of trazodone (10 mg/kg) (n = 5 mice). Data are means ± SEM (**P = 0.001; ****P ≤ 0.0001).