Fig. 5: Tsh regulation of gonadotrope cells is mediated via folliculostellate cells. | Communications Biology

Fig. 5: Tsh regulation of gonadotrope cells is mediated via folliculostellate cells.

From: Day length regulates gonadotrope proliferation and reproduction via an intra-pituitary pathway in the model vertebrate Oryzias latipes

Fig. 5

a The pituitary cell clusters identified by single-cell sequencing, showing three uncharacterized cell types (I–III). b, c tshr2 and cyp19a1b are specifically expressed in one of these uncharacterized cell types (III), with cyp19a1b also showing modest expression in other pituitary cell types (e.g. gonadotropes). Figures are UMAP projections generated using Seurat. Color scale: log-transformed relative expression level (maximized per gene). d–f Confocal planes showing co-expression of tshr2 and cyp19a1b in the same pituitary cells. Parasagittal section of brain and pituitary with a dashed line indicating the pituitary (A: anterior, P: posterior). Scale bar: 100 µm.

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