Fig. 8: KAT5 mitigates MIRI in mice through regulation of STUB1/LATS2/YAP/β-catenin pathway. | Communications Biology

Fig. 8: KAT5 mitigates MIRI in mice through regulation of STUB1/LATS2/YAP/β-catenin pathway.

From: STUB1 is acetylated by KAT5 and alleviates myocardial ischemia-reperfusion injury through LATS2-YAP-β-catenin axis

Fig. 8

The mice were administered adenoviruses containing sh-NC, shKAT5, NC, or KAT5 and then suffered I/R. The serum activities of LDH (a) and CK-MB (b) were measured. c LVEF and LVFS were assessed by echocardiography. d Western blotting analysis of KAT5, STUB1, LATS2, YAP, β-catenin, NLRP3, ASC, Caspase-1, IL-18, IL-1β expression in heart tissues. e Immunohistochemical staining detected KAT5, STUB1, LATS2, YAP, β-catenin, and NLRP3 expression in the heart tissues (brown color indicates positive staining, scale bar = 100 μm). f The levels of IL-18 and IL-1β were measured by ELISA in heart homogenate. Data represent the mean ± SD. n = 5 animals. One-way ANOVA followed by Bonferroni was performed for statistical analysis in a-c. Box plots represent median with minimum and maximum whiskers. *p < 0.05, **p < 0.01, ***p < 0.001 versus indicated group.

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