Fig. 3: GFI1B variants exert different transcriptomic changes in MEG01 cells.
From: GFI1B and LSD1 repress myeloid traits during megakaryocyte differentiation
a Weighted Gene Co-Expression Network Analysis revealed 12 modules, of which 10 modules were significant in at least one condition (see Supplementary Data 1). Module 12 contains all genes that were not be assigned to a module and module 6 did not return a significant correlation with any condition. Every condition had at least one significantly correlating module except for GFP. The strongest and most significant correlation was found between module 10 and GFI1BQ287*. b Expression analysis of all module genes showed that high module correlation indeed corresponded to high expression of those genes in that condition. Unsupervised hierarchical clustering grouped all replicates of a condition together. c REACTOME enrichment for module 10 using g:Profiler. Most genes in module 10 belonged to pathways that are involved in the innate immune system and homeostasis.
