Fig. 4: Expression of the genes in the OT pathway across the body.
From: An evolutionary timeline of the oxytocin signaling pathway
a Differential expression of genes from the OT signaling pathway in 30 tissue types from the GTEx dataset. Significantly enriched tissues are colored, with colors corresponding to the bar plots to the right. b Ancient OT pathway genes (n = 28) were not significantly differentially expressed (e.g., up- or downregulated) in any tissue. c Expression of the medium-aged genes (n = 28) is enriched in blood vessels and the bladder. d Modern genes (n = 98) are upregulated in skeletal muscle tissue and the brain. −Log 10 P values from hypergeometric tests. The raw data underlying plots (b–d) is presented in Supplementary Data 11.
