Fig. 5: Expression of the modern OT pathway genes across the human brain.
From: An evolutionary timeline of the oxytocin signaling pathway
a Mean expression values of the modern OT gene set in eight subcortical regions (bold black dots) compared to the average expression of the modern OT gene set across the whole brain (i.e., the total of 42 brain regions, cortical and subcortical, vertical black dashed line; for reference the vertical gray dashed line represents mean expression across subcortical regions). Jittered colored dots represent the mRNA intensity of each single modern OT gene, the three gray dots in each distribution represent mRNA intensities of OXT, OXTR and CD38. *PFDR < 0.05. Ridge plots are colored and ranked by mean expression intensity. b Atlas representation of the t values in 34 cortical brain regions (unilateral left). High t-statistics can be observed in the precentral gyrus, posterior cingulate, pars opercularis, and superior frontal gyrus (statistically significant), the lowest value appears in the cuneus. The raw data underlying these plots is presented in Supplementary Data 12 and 13. n = 81 (98) genes and postmortem expression data from n = 6 brains included in the analysis.
