Fig. 1: Study workflow.
From: Metabolic network analysis of pre-ASD newborns and 5-year-old children with autism spectrum disorder
Metabolomics was used to interrogate real-time gene-environment interactions. The purine metabolic network was the most changed of 50 biochemical pathways analyzed in autism spectrum disorder. Developmental reversal of the excitatory (+r) to inhibitory (ār) purine network was a feature of neurotypical development. This reversal did not occur in children with ASD. ASD autism spectrum disorder, TD typically developing.
