Fig. 2: Metabolic changes in ASD.
From: Metabolic network analysis of pre-ASD newborns and 5-year-old children with autism spectrum disorder
a, b Multivariate partial least squares discriminant analysis (PLS-DA). Cross-validation accuracy, r2, q2, and permutation p values are reported for a multivariate model with three components. c, d The magnitude of metabolic differences between ASD and TD increased with age. ****p < 0.0001. e, f Metabolite changes and pre-ASD newborns and 5-year-olds with ASD ranked by variable importance in projection (VIP) scores. g, h Bubble impact plot summary of biochemical pathway changes ranked by random forest analysis and mean decrease in accuracy (MDA). n = 205 newborns (68 males and 17 females in the pre-ASD group. 68 males and 52 females in the TD group), n = 53 5-year-olds (23 males and 8 females with ASD. 16 males and 6 females in the TD group).
