Fig. 5: IL-1α is sufficient as a vaccine adjuvant to generate protective immunity against K. pneumoniae.
From: Vaccine-elicited IL-1R signaling results in Th17 TRM-mediated immunity
Log transformed bacterial burdens in the (a) lungs and (b) spleen 24 h post-challenge of C57Bl/6 mice immunized as indicated (n = 7, OmpX+rIL-1α; n = 3, OmpX+rIL-1β; n = 8, PBS). c Serum IgG titers specific to OmpX from each vaccinated group as measured in ELISA (n = 3 mice per group). d ELISpot measuring IL-17A secreting cells after overnight stimulation with OmpX. Data are displayed as spot counts (SFU) per 105 plated cells from lung homogenate (n = 2 mice per group). All data are presented as mean +/− SEM. Statistical differences were determined using a one-way ANOVA followed by Tukey’s multiple comparison test.
