Fig. 6: Inhibition of HO-1 alters mitochondria-related gene expression profile in CLI.
From: Activation of Nrf2/HO-1 signaling pathway exacerbates cholestatic liver injury
a Principal Component Analysis (PCA) of RNA-seq data from mice fed a control, OA, and OA combined ZnPP diet for 4 days (n = 3). b, c Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis (control vs OA). The outer circle indicates the upregulation and the inner circle indicates the downregulation. d, e Heatmap of mitochondrial-related and oxidative phosphorylation-related genes. Red indicates the upregulation, and blue indicates the downregulation in heatmaps. Data set. n = 3 per group. RNA-seq, RNA sequencing.
