Table 1 GWAS summary data used for analysis

From: Genome-wide cross-disease analyses highlight causality and shared biological pathways of type 2 diabetes with gastrointestinal disorders

Data

Cases

Control

N

Ancestry

Phenotype source/definition

T2D (Mahajan et al.)83

74,124

824,006

898130

European

T2D data from the DIAGRAM consortium

T2D adjusted for BMI83

74,124

824,006

898130

T2D data from the DIAGRAM consortium

GERD (UKB_QSKIN, An et al.)84

71,522

261,079

332,601

Data from the UKB and the QSKIN study

PUD (Wu et al.)43

16,666

439,661

456,327

UKB data code described in Wu et al. 2021

Gastritis-duodenitis Phecode 535 (Lee Lab)

28,941

378,124

407,065

Full White British samples from the Lee Lab

IBS (Wu et al.)43

28,518

426,803

455,321

UKB data code described in Wu et al. 2021

Diverticulosis and diverticulitis Phecode 562 (Lee Lab)

27,311

334,783

362,094

Full White British samples from the Lee Lab

IBD (Wu et al.)43

7045

449,282

456,327

UKB data code described in Wu et al. 43

PGM (Wu et al.)43

90,175

366,152

456,327

Phenotype combining PUD and GERD and/or corresponding medications/treatments.

Data for further analyses, replication or adjustment in the multivariable MR analysis

GORD (Wu et al.)43

54,854

401,473

456,327

European

UKB data code described in Wu et al. 43

PUD Phecode 531 (Lee Lab)

7,436

401,525

408,961

Full White British samples from the Lee Lab

Gastritis-duodenitis (Watanabe et al.85)

14,477

286,314

300,791

Main ICD10: K29 Gastritis and duodenitis

IBS Phecode 564.1 (Lee Lab)

5,548

334,783

340,331

Full White British samples from the Lee Lab

Diverticular disease (Watanabe et al. 85)

14,028

286,763

300,791

Main ICD10: K57 Diverticular disease

IBD (Liu et al. 2015)

12,882

21,770

34,652

Data from the IBD genetic consortium

Lansoprazole (Watanabe et al.85)

13,559

266,884

280,443

UKB treatment/medication code lansoprazole

T2D (Xue et al.)44

62,832

596,424

659256

A meta-analysis combining DIAGRAM, GERA, and the full cohort release of the UKB.

UKB T2D Phecode 250.2 (Lee Lab)

18,945

388,756

407,701

Full British samples from the Lee Lab

BMI (GWAS Atlas ID: 3445)85

  

379,831

GWAS data from the UKB

BMI (Yengo, et al.)45

  

681,275

GWAS data from the GIANT Consortium

  1. DIAGRAM DIAbetes Genetics Replication and Meta-analysis, GERA Genetic Epidemiology Research on Aging, UKB United Kingdom Biobank, ICD International Classification of Diseases, T2D type 2 diabetes, GERD (or GORD) gastroesophageal reflux disease, PGM medicated phenotype for GERD and PUD, PUD peptic ulcer disease, IBS irritable bowel syndrome, IBD inflammatory bowel disease, BMI body mass index, N sample size. Phecode 562 comprises diverticulosis and diverticulitis, reflecting this study’s definition of diverticular disease.
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