Fig. 1: Schematic of the CaMKII holoenzyme subunit composition and organization.
From: Hub stability in the calcium calmodulin-dependent protein kinase II
a The subunit is composed of a kinase domain (KD in blue), a regulatory segment (R in yellow), a linker (in black), and an association domain (AD in pink). b The subunit architecture of the CaMKIIβ holoenzyme. The AD forms the central hub (dashed hexagon). The peripheral KDs radiate out from the hub connected by flexible linkers that vary between isoforms. The regulatory segment, R, can alternate between multiple conformations within a single subunit. Alanine mutagenesis silences the activating (T287) and inhibitory (T306, T307) autophosphorylation sites.
