Fig. 1: Identification of RARA related to ferroptosis. | Communications Biology

Fig. 1: Identification of RARA related to ferroptosis.

From: Retinoic acid receptor alpha inhibits ferroptosis by promoting thioredoxin and protein phosphatase 1F in lung adenocarcinoma

Fig. 1: Identification of RARA related to ferroptosis.

a The volcano plot showed the differentially expressed genes in the FIN-treated group vs. the non-treated group, and RARA was upregulated in the FIN-treated group (A549 cell: RSL3 1 μM and IKE 2.5 μM for 48 h). b Venn plot displayed the ferroptosis-related transcription factors by the intersection of upregulated DEGs in RSL3-treated and IKE-treated groups in A549 cells. c, d qRT-PCR and WB verified the expression of RARA in the FIN-treated group vs. the non-treated group in A549, PC9, H23, and H2122 cells. (n = 3 biologically independent experiments, Student t-test). e qRT-PCR and WB showed the upregulation of RARA by other FINs (erastin 10 μM and FAC 50 μM for 48 h) (n = 3 biologically independent experiments, Student t-test) *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.

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