Fig. 5: Localization of target organs by in vivo imaging. | Communications Biology

Fig. 5: Localization of target organs by in vivo imaging.

From: Stomach as the target organ of Rickettsia heilongjiangensis infection in C57BL/6 mice identified by click chemistry

Fig. 5

a Images of stomach of C57BL/6 mice infected with DBCO-Cy7-conjugated N3-R. heilongjiangensis on day 5 after intradermal (i.d.) inoculation and intraperitoneal (i.p.) inoculation. The stomachs of infected WT-R. heilongjiangensis-mice served as the control. n = 3 stomachs per group. The color bar is the reference for the radiance scale ([p/sec/cm2/sr]/[μW/cm2]). Scale bar = 7 mm. b Average radiant efficiency (fluorescence intensity) of skin and stomach on 5 days post infection (dpi) via intradermal (i.d.) inoculation. The average radiant efficiency was quantified using Living Image software. The black column indicates the average radiant efficiency of control-mice. The red column indicates the average radiant efficiency of N3-R. heilongjiangensis-mice. The change is the average radiant efficiency in the organs of N3-R. heilongjiangensis infected mice compared to WT-R. heilongjiangensis infected mice. n = 3 biologically independent samples. Error bars represent geometric means ± SD.

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