Fig. 1: miR-145-5p is upregulated in chronic lesion tissue from SPMS brains. | Communications Biology

Fig. 1: miR-145-5p is upregulated in chronic lesion tissue from SPMS brains.

From: Loss of miR-145 promotes remyelination and functional recovery in a model of chronic central demyelination

Fig. 1: miR-145-5p is upregulated in chronic lesion tissue from SPMS brains.

a, b Luxol fast blue/hematoxylin and eosin stained human brain tissue from healthy control white matter (HCWM), and normal appearing white matter (NAWM), active and chronic inactive lesion tissue from SPMS brain. a Scale bar = 1 mm. b Magnified from (a); scale bar = 50 µm. c Relative expression of miR-145-5p in HC and NAWM, active and chronic inactive lesion tissue from SPMS brain. Analysed by ΔΔCt, normalized to snU6. N = 4–5, **p < 0.01, one-way ANOVA with Tukey’s post hoc.

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