Table 1 Expression of miR-145-5p is elevated in chronic inactive lesion tissue from SPMS and RRMS patients
Disease | Sex | Age (yrs) | Disease duration (yrs) | EDSSa | Tissue type | miR-145-5p expression ± SEM | FCb/mean HCc |
|---|---|---|---|---|---|---|---|
SPMSd | M | 61 | 26 | 9.5 | NAWMf | 0.67 ± 0.01 | 1.58 |
Chronic Inactive | 1.27 ± 0.03 | 3.00 | |||||
Active | 0.39 ± 0.04 | 0.93 | |||||
SPMS | M | 65 | 13-15 | 9 | NAWM | 0.45 ± 0.01 | 1.06 |
Chronic Inactive | 3.64 ± 0.20 | 8.59 | |||||
Chronic Inactive | 3.29 ± 0.12 | 7.77 | |||||
Active | 0.20 ± 0.01 | 0.48 | |||||
SPMS | F | 60 | 28 | 8.5 | NAWM | 0.53 ± 0.01 | 1.25 |
Chronic Inactive | 1.36 ± 0.08 | 3.21 | |||||
Active | 0.41 ± 0.02 | 0.96 | |||||
SPMS | M | 48 | 6 | 8.5 | NAWM | 0.63 ± 0.03 | 1.48 |
Chronic Inactive | 1.84 ± 0.05 | 4.36 | |||||
Active | 0.27 ± 0.01 | 0.63 | |||||
RRMSe | M | 26 | 12 | 9 | NAWM | 0.43 ± 0.01 | 1.03 |
Chronic Inactive | 2.28 ± 0.03 | 5.40 | |||||
Active | 0.33 ± 0.02 | 0.79 | |||||
HC | M | 64 | -- | -- | WMg | 0.17 ± 0.00 | -- |
HC | M | 67 | -- | -- | WM | 0.46 ± 0.02 | -- |
HC | F | 37 | -- | -- | WM | 0.68 ± 0.02 | -- |
HC | M | 42 | -- | -- | WM | 0.38 ± 0.01 | -- |
