Table 1 Intra-study reproducibility of the pancreas-liver MPS

From: Normoglycemia and physiological cortisone level maintain glucose homeostasis in a pancreas-liver microphysiological system

On-chip readout

Study

# of circuits

# of time points

Max CV

ICC

Reproducibility status

Healthy condition

Albumin

1

10

7

25.2

0.805

2

8

7

17.1

0.743

3

8

7

26.3

0.349

Ketone bodies

1

8

2

7.6

0.422

2

8

2

13.2

0.464

3

8

2

15.4

0.355

IL-1R2

2

4

3

46.3

0.969

3

4

3

49.9

0.665

GTT Insulin

1

4

4

9.4

0.908

2

4

4

2.9

0.960

GTT Glucose

1

4

4

20.0

0.953

2

4

4

61.6

0.927

Diseased condition

Albumin

1

6

7

36.5

0.581

2

4

7

37.1

0.479

3

4

7

20.7

0.890

Ketone bodies

1

6

2

16.3

0.843

2

4

2

38.2

0.459

3

4

2

38.0

0.294

IL-1R2

2

4

3

14.5

0.939

3

4

3

7.3

0.977

GTT Insulin

1

4

4

3.5

0.724

2

4

4

5.1

0.882

GTT Glucose

1

4

4

50.6

0.905

2

4

4

48.1

0.946

  1. Statistical assessment of the reproducibility is based on intra-class correlation coefficient (ICC) and the maximum coefficient of variation (CV). Reproducibility is classified as “Excellent” if Max CV ≤ 5% or ICC ≥ 0.8; “Acceptable” if 5% < Max CV < 15% or 0.2 ≤ ICC < 0.8; or “Poor” if ICC < 0.2. Studies 1 and 2 were performed at TissUse and Study 3 at AstraZeneca.
Back to article page