Fig. 6: OLFM4^ΔRORc mice decreases the amount of ILC3 and IL-22 production.

Statistical results of proportion and absolute numbers of CD4⁺RORγt⁺ cells under (A) C. rodentium infection (n = 5) and (B) anti-CD40 antibody-induced colitis (n = 5). Statistical results of the proportion and absolute numbers of ILC3 in LPMCs under (C) C. rodentium infection (n = 4) and (D) anti-CD40 antibody-induced colitis (n = 5). Statistical results of the proportion and absolute numbers of IL-22-expressing ILC3 in (E) C. rodentium infected mice (n = 4) and (F) anti-CD40-treated mice (n = 4). The proportion of Ki67⁺ILC3 in LPMCs from (G) C. rodentium infected mice (n = 6) and (H) anti-CD40-treated mice (n = 4). The proportion of Annexin V⁺ILC3 in LPMCs under (I) C. rodentium infection (n = 4) and (J) anti-CD40 induced colitis (n = 4). Data are presented as mean ± SEM, and statistical significance was determined using a two-tailed unpaired Student’s t-test (A–J). ns, not significant; *P < 0.05; **P < 0.01; ***P < 0.001. The experiments were performed three times (at least three replicates).