Fig. 3: General changes induced by individual treatments across all muscles.

A Kinase and functionally-annotated phosphorylation sites that are significantly altered by AGE in all muscles (log2 fold changes capped at ±1). Relative changes in phosphopeptide intensity are shown for all muscles and all conditions. The site coordinate within the protein is shown, along with the protein kinase known to phosphorylate the site. If a phosphosite was covered by multiple peptides, the individual peptides are shown, indicated by an additional number in the name. B Biological processes in which the phosphorylation sites from (A) play a role according to the PhosphoSitePlus database. The direction of the phosphorylation signal change is indicated by the red (increase) and blue (decrease) color of the phosphate symbol, and the effect of the phosphorylation on the process is indicated by the color of the arrows leading to the respective process, black for repression and green for activation. If the phosphorylation modifies the activity of the substrate protein, the activity change upon phosphorylation is indicated by the arrow leading to the substrate (black - inhibition, green - activation). C Similar to (B), for CR-altered sites. D Same as in (C), for CR-altered phosphopeptides. E Similar to (B), for RM-altered sites. F Same as in (C), for RM-altered phosphopeptides.