Fig. 4: Conserved but unannotated protein phosphorylation sites in muscles of aged, treated and untreated mice. | Communications Biology

Fig. 4: Conserved but unannotated protein phosphorylation sites in muscles of aged, treated and untreated mice.

From: Calorie restriction and rapamycin distinctly mitigate aging-associated protein phosphorylation changes in mouse muscles

Fig. 4: Conserved but unannotated protein phosphorylation sites in muscles of aged, treated and untreated mice.

A Top: Venn diagram showing the overlap between phosphosites that responded consistently across all four muscles in AGE, CR, and RM treatments. Shown are sites without an annotated kinase. Bottom: log2 fold changes in the intensity of the indicated peptides in each condition and each of the four muscles. Shown are the phosphopeptides that changed significantly and consistently in all muscles in all three conditions. Same as in (A) but conditioned on significant and consistent changes across muscles in AGE and CR (B), AGE and RM (D) and CR and RM (E). C Significantly enriched biological processes (GO terms) in proteins with consistently changing phosphosite in AGE and CR. F Same as (C) but for proteins with consistently changing phosphosite in CR and RM.

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