Fig. 8: Graph summary.
From: Rhein targets macrophage SIRT2 to promote adipose tissue thermogenesis in obesity in mice
During obesity, rhein promotes adipose tissue thermogenesis by suppressing the activation of NLRP3 inflammasome in adipose tissue-resident macrophages. Furthermore, SIRT2 is a direct molecular target of rhein, and rhein inhibits the activation of NLRP3 inflammasome and promotes adipose tissue thermogenesis in a macrophage SIRT2-dependent manner.
