Fig. 1: Bactericidal activity of Peptoids TM1, TM5, and TM6.
From: Peptide-mimetic treatment of Pseudomonas aeruginosa in a mouse model of respiratory infection
Relative luminescence (A) and CFUs/mL (B) for P. aeruginosa Xen41 treated with 2-fold dilutions of TM1, TM5, and TM6. A TM1, TM5, and TM6 were all significantly different from the no treatment control with respect to their relative luminescence at concentrations of 1 μg/ml and higher. B TM1 was significantly different from the no treatment control for CFUs/mL at concentrations of 0.5 μg/mL and above, while TM5 and TM6 were significantly different at 2 and 4 μg/ml respectively. Data points are represented as means (n=replicates). Error is shown in ± standard deviation (SD). Statistics were performed using 2-way ANOVA, comparing antimicrobial to no treatment control. P values are: <0.001 = ***, between 0.001 and 0.01 = **, and between 0.01 and 0.05 = *.
