Fig. 6: Comparison of the open conformation of falcilysin and human presequence protease. | Communications Biology

Fig. 6: Comparison of the open conformation of falcilysin and human presequence protease.

From: Inhibition of falcilysin from Plasmodium falciparum by interference with its closed-to-open dynamic transition

Fig. 6

A The open conformation of FLN displayed as ribbons (this work, PDB accession number: 8WYY) and hPreP (PDB accession number: 6XOU); N-half are colored in cyan; C-half: green; hinge helix: red; linker region of FLN: purple. Disordered regions are indicated by dashes. B Closed conformation of FLN (this work, PDB accession number: 7DIJ) and hPreP (PDB accession number: 4RPU). The same color code as in panel (A) is used. Both allosteric inhibitors MK4815 (this work) and MB60 (PDB code: 4RPU) are displayed as gray spheres and bind next to the hinge region, impeding the dynamics of the metalloprotease.

Back to article page