Fig. 1: FZA inhibited NSCLC growth both in vivo and in vitro. | Communications Biology

Fig. 1: FZA inhibited NSCLC growth both in vivo and in vitro.

From: Alkaloids of Aconiti Lateralis Radix Praeparata inhibit growth of non-small cell lung cancer by regulating PI3K/Akt-mTOR signaling and glycolysis

Fig. 1: FZA inhibited NSCLC growth both in vivo and in vitro.

A Tumor volume growth curves of the mice. B Tumor weight of the mice at the end of the experiment. C Changes in body weight of the mice. D H&E staining of the tumor sections. E Histological analysis of the major organs slices after treatments. The scar bar was 100 µm. F The viscera indexes of lung, heart, spleen, liver, kidney of the mice were calculated. G The cytotoxic activities of FZA against NSCLC cells for 72 h. IC50 value were evaluated by Graph Prism. The red line, green line, and black line respectively represented the first, second, and third time of MTT experiment. (n =  3) (H) Cell viability assay treated with different doses of FZA (n = 3). Data were presented as the mean ± SD. Error bars indicated SD. *p < 0.05, **p < 0.01; ***p < 0.001. All data were from three independent experiments.

Back to article page