Fig. 3: The mechanism of FZA in treatment of NSCLC was analyzed by TMT-based proteomics. | Communications Biology

Fig. 3: The mechanism of FZA in treatment of NSCLC was analyzed by TMT-based proteomics.

From: Alkaloids of Aconiti Lateralis Radix Praeparata inhibit growth of non-small cell lung cancer by regulating PI3K/Akt-mTOR signaling and glycolysis

Fig. 3: The mechanism of FZA in treatment of NSCLC was analyzed by TMT-based proteomics.

A The volcano plot showed the upregulated (red) and downregulated (green) proteins between FZA and model groups. B Hierarchical cluster analysis of 238 DEPs. The colors indicated fold changes of the proteins, the blue color indicated an increase while red indicated a decrease. C The top 20 core genes were analyzed by MCODE. D KEGG pathways of FZA against NSCLC. The gradual color represented the P value and the size of the black spots represented the gene number enriched in the pathways. E GO analysis of the 238 DEPs in biological process, cellular component, and molecular function respectively. F The key proteins were uploaded to the CluoGO plug-in of Cytoscape for analyzing biological processes.

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