Fig. 3: Bar plots demonstrating monotonically increasing trends between exposure groups and cytokines levels.

Effect sizes of a CRP, b sCD14, and c sCD163 levels from participants’ plasma samples (N = 241) were shown here. The X-axis details the exposure groups of participants (N = 241), from G1 to G4. The Y-axis reflects the cytokine’s effect size determined by the CLME model. It is important to note that these are not raw concentrations but fitted values under a monotonic trend. Each bar’s error bars denote the 95% CI. Pairwise p-values (one-sided), used for contrasting the exposure groups, are displayed above the brackets that span the respective bars. The p-value for a monotonically increasing trend is provided within the plot.