Fig. 2: Crystal structure of BCORN1607/PCGF1RAWUL dimer in complex with KDM2BLRRs. | Communications Biology

Fig. 2: Crystal structure of BCORN1607/PCGF1RAWUL dimer in complex with KDM2BLRRs.

From: Calcium modulates the tethering of BCOR-PRC1.1 enzymatic core to KDM2B via liquid-liquid phase separation

Fig. 2

A Structure of BCORN1607/PCGF1RAWUL/KDM2BLRRs heterotrimer is presented as cartoon. BCORN1607, PCGF1RAWUL and KDM2BLRRs are colored as magenta, yellow and blue, respectively. Residues for BCORN1607 interacting with KDM2BLRRs are shown as stick. B Binding affinity between BCORANK-linker-PUFD (wild type or P1620A/P1621A mutant)/PCGF1RAWUL and KDM2BF-box-LRRs (wild type or W1143A mutant)/SKP1 was measured using ITC. The Kd values are shown as mean ± SD for triplicate experiments. C Sequence alignment of BCORlinker among species from zebrafish to human. NPPGP motif on linker of BCOR is boxed with magenta dash.

Back to article page