Fig. 8: Convergent BCR sequences exhibit specific binding to ST3. | Communications Biology

Fig. 8: Convergent BCR sequences exhibit specific binding to ST3.

From: Full-length single-cell BCR sequencing paired with RNA sequencing reveals convergent responses to pneumococcal vaccination

Fig. 8

a Plots of recombinant Rhesus-murine chimeric antibodies binding to ST3 as a function of concentration and IGHV gene. Each line represents an antibody selected from a single clone. b Heatmap of antibody binding to 93 different pneumococcal serotypes as a function of IGHV gene family and monkey. The values are shown for MFI measured with 2.3 µg/L of antibody by Luminex. The full list of serotypes evaluated is provided in the Supplementary Data 2.

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