Fig. 3: The results of resting-state BOLD and cognition-related behavior tests of model mice.
From: Atoh1 mediated disturbance of neuronal maturation by perinatal hypoxia induces cognitive deficits
a ReHo analysis of control and model mice at P60 (p < 0.05) (control, n = 6; model, n = 6). b ALFF analysis of control and model mice at P60 (p < 0.05) (control, n = 6; model, n = 6). The bregma for each layer of the brain map is shown below the image in the (a, b). The green arrows indicate changes of brain regions. c Top left: schematic of the OF tests. Top right: bar graphs show the total distance traveled in OF and time in inner space (control + NC, n = 6; model + NC, n = 6; model + OE-Atoh1, n = 6) (For statistics, see Table S12). Bottom: Sample tracing of mice in OF. d The most left panels: schematic of the NOR tests. The right three panels: Sample tracing of mice in training and testing sessions. Bar graph in bottom left panel shows the discrimination index. Bar graphs in bottom right panel show the exploration time of the familiar and novel object (control + NC, n = 6; model + NC, n = 6; model + OE-Atoh1, n = 6) (discrimination index, F = 17.49, df = (15, 2) control + NC vs model + NC, **p = 0.0020; control + NC vs model + OE-Atoh1, **p = 0.0010; model + NC vs model + OE-Atoh1, *p = 0.049 (0.16 ± 0.0087 vs 0.10 ± 0.013 vs 0.068 ± 0.011); exploration time, for statistics, see Table S13. e The left panel: schematic of the Skinner’s box tests. The right panel: Bar graphs show accuracy of mice in probing the correct hole to achieve reward in the first stage and the second stage (control + NC, n = 6; model + NC, n = 6; model + OE-Atoh1, n = 6) (For statistics, see Table S14). All data were shown as mean ± SEM. *p < 0.05, **p < 0.01.
