Fig. 1: Study of mitochondrial bioenergetics and dynamics coupling.

Glucose and inhibitors of the mitochondrial respiratory chain induced different mitochondrial responses and morphological changes in INS-1 cells. Image analyses were used to quantify the changes in fluorescence microscopy images of mitochondria under metabolic challenges. Computational models that coupled mitochondrial bioenergetics and mitochondrial dynamics were used to simulate and explain the experimental observations.