Table 1 MIC values of SMJ-2 and SMJ-4 against various strains

From: Synthetic indole derivatives as an antibacterial agent inhibiting respiratory metabolism of multidrug-resistant gram-positive bacteria

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Strain

SMJ-2

SMJ-4

Oxacillin

Vancomycin

Ciprofloxacin

Erythromycin

 

MIC (µg mL−1)

MIC (µg mL−1)

MIC (µg mL−1)

MIC (µg mL−1)

MIC (µg mL−1)

MIC (µg mL−1)

Staphylococcus aureus

S. aureus SA-1199B

2

4

≤1

2

8

16

ATCC 29213 (MSSA)

2

4

0.25

1

0.5

0.25

ATCC 25923 (MSSA)

1

1

≤1

≤1

≤1

0.125

ATCC 43300 (MRSA)

2

4

64

1

≤1

0.25

ATCC 33591 (MRSA)

2

4

>128

1

0.5

>128

ATCC-BAA-1717 (MRSA)

2

4

128

1

≤1

>256

ATCC-BAA-39* (MRSA)

2

4

64

1

8

>256

GMCH 839 (MRSA)

2

16

2

1

8

>128

GMCH 4241 (MSSA)

1

4

≤1

≤1

16

>128

GMCH 6188* (MRSA)

1

2

>128

2

8

>500

GMCH 6187* (MRSA)

2

2

>128

≤1

16

64

GMCH 6152 (MRSA)

1

2

16

2

32

≤1

GMCH 3939* (MRSA)

2

16

4

1

>16

>128

GMCH 6022 (MRSA)

2

16

4

≤1

128

4

MRSA-1*

1

1

4

1

8

>500

MRSA-2*

1

16

4

1

8

>128

MRSA-3*

2

2

4

1

8

>500

MRSA-4*

1

16

4

1

32

>128

Enterococcus faecium

ATCC 51559* (VRE)

2

2

>128

500

8

128

ATCC 19434*

2

4

8

≤1

32

128

Enterococcus faecalis

ATCC 29212

2

2

8

2

≤1

32

ATCC 51299* (VRE)

0.25

0.25

32

128

≤1

≥128

Bacillus subtilis

ATCC-6633

2

4

≤1

≤1

≤1

>128

MTCC-121

2

4

≤1

≤1

2

>128

Streptococcus mutans

MTCC 497

2

4

≤1

2

≤1

>128

Escherichia coli

ATCC 25922

≥64

≥64

64

128

≤1

>128

ATCC BAA 2774

≥64

≥64

>128

>128

>128

>128

Pseudomonas aeruginosa

ATCC BAA 2795

≥32

≥32

>128

>128

>128

>128

Acinetobacter baumannii

ATCC 19606

≥16

≥16

≥128

≥128

≤1

>128

  1. (*) Indicates multidrug-resistant strain.
  2. MSSA Methicillin-sensitive Staphylococcus aureus, MRSA Methicillin-resistant Staphylococcus aureus, VRE Vancomycin resistant Enterococcus faecium/Vancomycin resistant Enterococcus faecalis.
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