Fig. 6: Inflammation mimicking non-bacterial prostatitis promotes the proliferation of basal stem cells and the basal to luminal differentiation in vivo. | Communications Biology

Fig. 6: Inflammation mimicking non-bacterial prostatitis promotes the proliferation of basal stem cells and the basal to luminal differentiation in vivo.

From: Inflammation impacts androgen receptor signaling in basal prostate stem cells through interleukin 1 receptor antagonist

Fig. 6: Inflammation mimicking non-bacterial prostatitis promotes the proliferation of basal stem cells and the basal to luminal differentiation in vivo.

A Quantitation of BrdU+ bPSC in naïve and inflamed prostates, with or without castration (All groups, n = 4). B Percentage of bPSC in naïve and inflamed prostates, with or without castration (All groups, n = 4). C Experimental scheme showing time points of inflammation, castration and analysis. D AR staining shows maintenance of AR nuclear localization (arrow heads) in castrated inflamed prostates (Scale bar, 20 μm). E, F Quantitation of GFP+ cells or foci within the luminal layer (Naïve, n = 6; Naïve_castration, n = 4; Inflamed, n = 6; Inflamed_castration, n = 5). G Representative immunofluorescent images from naïve and inflamed prostates with or without castration showing the presence of GFP + CK5+ cells within the CK8+ luminal layer (arrowheads) (Scale bar, 50 μm). H, I Size of GFP+ foci and percentage of GFP+ foci of different sizes within the luminal layer (Naïve, n = 6; Naïve_castration, n = 4; Inflamed, n = 6; Inflamed_castration, n = 5). Data presented in this figure are mean ± SEM.

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