Fig. 2: Expression changes of miRNAs during mouse cerebral cortex development. | Communications Biology

Fig. 2: Expression changes of miRNAs during mouse cerebral cortex development.

From: Stage-specific expression patterns and co-targeting relationships among miRNAs in the developing mouse cerebral cortex

Fig. 2

a Principal component analysis of bulk small RNA sequencing samples from the cerebral cortex of female and male mice at different developmental stages. n = 4 biological replicates for females at E14, n = 6 in all remaining groups. b Venn-diagram of upregulated miRNAs at earlier compared to later stages of cortical development. c Venn-diagram of downregulated miRNAs at earlier compared to later developmental stages. d–f Volcano plots of differentially expressed miRNAs. Positive log2 fold changes indicate miRNAs upregulated at earlier compared to later developmental stages in each pairwise comparison (E14 vs. E17, E14 vs. P0 and E17 vs. P0). g Heatmap of miRNAs differentially expressed in each pairwise comparison of different developmental stages. Mean expression values per developmental stage are shown as z-scores.

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