Fig. 1: Blp bacteriocins contribute to severe pneumonia. | Communications Biology

Fig. 1: Blp bacteriocins contribute to severe pneumonia.

From: Pneumococcal pneumonia is driven by increased bacterial turnover due to bacteriocin-mediated intra-strain competition

Fig. 1

A Burden of Spn strains per gram of lung tissue at 1 & 2 dpi. Whiskers on the plot show min to max values. B–E Spn undergoes extensive turnover in the lungs. B, C Graphs depict B Hill’s N1 (clonal diversity) and C proportion of the most abundant clone of WT Spn detected in the lung at 0 h & 2 dpi. D, E Graphs depict D fold change in Hill’s N1 (clonal diversity), and E proportion of most abundant clone for WT and Δblp strains at 1 dpi. F–H Burden of Spn strains per gram of (F, H) lung, and G spleen (Δblp & Δblp::blp: P = 0.0022 by Mann–Whitney test) at 2 dpi. Animals were infected with either A–G TIGR4, or H type 6A Spn strains. P values were calculated by (A) two-way ANOVA followed by Tukey’s multiple comparisons, (B–E) two-tailed t test, and (F–H) Kruskal–Wallis test followed by Dunn’s multiple comparisons. Each dot represents an individual animal (Geometric mean ± 95% CI). I Table represents survival of mice inoculated with TIGR4 and Type 6A Spn strains until humane end point at 2 dpi. P values denote comparison with WT by Mantel–Cox test. ‘ns’ denotes statistically not significant.

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