Fig. 3: Expression of imprinted genes in SOBS/CTS double-mutant mice. | Communications Biology

Fig. 3: Expression of imprinted genes in SOBS/CTS double-mutant mice.

From: Identification of responsible sequences which mutations cause maternal H19-ICR hypermethylation with Beckwith–Wiedemann syndrome-like overgrowth

Fig. 3

Expression levels of Igf2 (a) and H19 (b) in H19-ICRmSOC1/+ (WT and H19-ICRmSOC1/+; n = 8 and n = 8, respectively, from 2 litters), H19-ICRmSOC2/+ (WT and H19-ICRmSOC2/+; n = 4 and n = 6, respectively, from 2 litters), H19-ICRmSOC3/+ (WT and H19-ICRmSOC3/+; n = 9 and n = 4, respectively, from 3 litters), and H19-ICRmSOC4/+ (WT and H19-ICRmSOC4/+; n = 8 and n = 6, respectively, from 3 litters) tissues. White and red bars indicate WT and H19-ICRmSOC1-4/+ tissues, respectively. Error bars indicate standard deviation. P-values are indicated (unpaired two-tailed t-test). ns; not significant. c Allelic expression of Igf2 in WT and H19-ICRmSOC1-4/+ neonates. Representative electropherograms of the RT-PCR products are shown.

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