Fig. 4: The phenotypes of SOBS/CTS double-mutant mice. | Communications Biology

Fig. 4: The phenotypes of SOBS/CTS double-mutant mice.

From: Identification of responsible sequences which mutations cause maternal H19-ICR hypermethylation with Beckwith–Wiedemann syndrome-like overgrowth

Fig. 4

a (Top) Body weights of neonates at 1 dpp in H19-ICRmSOC1/+ (WT and H19-ICRmSOC1/+; n = 11 and n = 9, respectively, from 3 litters), H19-ICRmSOC2/+ (WT and H19-ICRmSOC2/+; n = 13 and n = 11, respectively, from 3 litters), H19-ICRmSOC3/+ (WT and H19-ICRmSOC3/+; n = 26 and n = 19, respectively, from 5 litters), and H19-ICRmSOC4/+ (WT and H19-ICRmSOC4/+; n = 24 and n = 20, respectively, from 5 litters). White and red dots indicate individual weights of WT and heterozygous mutants with maternally transmitted H19-ICRmSOC1-4 alleles, respectively. Horizontal and error bars indicate the mean ± SD, respectively. (bottom) Representative photographs of H19-ICRmSOC3/+ neonates and WT littermates. The arrow indicates umbilical hernia. The liver (b) and tongue (c) weights of neonates at 1 dpp: H19-ICRmSOC1/+ (WT and H19-ICRmSOC1/+; n = 11 and n = 9, respectively, from 3 litters), H19-ICRmSOC2/+ (WT and H19-ICRmSOC2/+; n = 6 and n = 9, respectively, from 2 litters), H19-ICRmSOC3/+ (WT and H19-ICRmSOC3/+; n = 9 and n = 13, respectively, from 3 litters), and H19-ICRmSOC4/+ (WT and H19-ICRmSOC4/+; n = 19 and n = 6, respectively, from 3 litters). P-values are indicated (unpaired two-tailed t-test). ns; not significant.

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